产品货号：
Z23235
中文名称：
PABPC4抗体
英文名称：
Anti-PABPC4 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PABPC4 Antibody |
| 指标别名 | Activated platelet protein 1;APP 1;APP1;iPABP;PABP 4;PABP4;PABPC4;Poly(A) binding protein 4 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF,ICC/IF,FCM |
| 基因名称 | PABPC4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence of human APP-1/PABPC4 (RPPYYTPNQLAQMRPNPRWQQ). |
| 实际分子量 | 75KD |
| 成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Polyadenylate-binding protein 4 (PABPC4) is a protein that in humans is encoded by the PABPC4 gene.Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein.Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold.PABPC4 contains 4 RNA-binding domains and proline-rich C terminus.PABPC4 is localized primarily to the cytoplasm.It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells.PABPC4 was also identified as an antigen,APP1 (activated-platelet protein-1),expressed on thrombin-activated rabbit platelets.PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.Alternatively spliced transcript variants encoding different isoforms have been found for this gene.This protein has also been found to interact with coronavirus nucleocapsid proteins and is thought to inhibit coronavirus replication. |
| Uniprot ID | Q13310 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | poly(A) binding protein cytoplasmic 4 |
| 蛋白名全称 | Polyadenylate-binding protein 4 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunofluorescence (IF) 1:50～400 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:50～400 Flow Cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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